Table 2.
Comparison of echocardiographic (UCG) findings between wild-type and Nedd4-2 C2-knockout mice. Male wild-type littermates (n = 5; 8–9 weeks old) and Nedd4-2 C2 −/− mice (n = 5; 8 weeks old) were used in this experiment. Data are expressed as means ± SE. Echocardiographic parameters showed no difference between wild-type and Nedd4-2 C2-knockout mice. IVSTd, intraventricular septal thickness in diastole; LVIDd, left ventricle internal diameter in diastole; LVPWTd, left ventricular posterior wall thickness in diastole; IVSTs, intraventricular septal thickness in systole; LVIDs, left ventricle internal diameter in systole; LVPWTs, left ventricular posterior wall thickness in systole; EDV, end diastolic volume; ESV, end systolic volume; SV, stroke volume; CO, cardiac output; EF, ejection fraction; FS, fractional shortening; HR, heart rate.
| UCG Measurements | Wild-Type | Nedd4-2 C2 −/− | p |
|---|---|---|---|
| (n = 5) | (n = 5) | ||
| IVSTd (mm) | 0.82 ± 0.02 | 0.81 ± 0.02 | 0.7717 |
| LVIDd (mm) | 4.28 ± 0.07 | 4.29 ± 0.04 | 0.9484 |
| LVPWTd (mm) | 0.73 ± 0.02 | 0.75 ± 0.02 | 0.3991 |
| IVSTs (mm) | 1.21 ± 0.03 | 1.15 ± 0.04 | 0.2290 |
| LVIDs (mm) | 3.00 ± 0.08 | 3.00 ± 0.05 | 0.9781 |
| LVPWTs (mm) | 0.92 ± 0.02 | 0.97 ± 0.02 | 0.0961 |
| EDV (μL) | 80.14 ± 3.99 | 79.08 ± 2.29 | 0.8291 |
| ESV (μL) | 28.76 ± 2.35 | 27.58 ± 1.28 | 0.6799 |
| SV (μL) | 51.38 ± 2.28 | 51.50 ± 1.69 | 0.9675 |
| CO (mL/min) | 24.95 ± 1.12 | 24.44 ± 0.89 | 0.7310 |
| EF (%) | 65.20 ± 1.68 | 65.21 ± 1.28 | 0.9955 |
| FS (%) | 30.16 ± 1.14 | 29.96 ± 0.86 | 0.8946 |
| HR (bpm) | 485.79 ± 5.33 | 473.46 ± 4.11 | 0.0819 |