Table 3.

Comparison of echocardiographic findings between wild-type and Nedd4-2 C2-knockout mice after myocardial infarction. Male wild-type littermates (n = 4; 11–14 weeks old) and Nedd4-2 C2 −/− mice (n = 4; 11–14 weeks old) were used for this experiment. Data are expressed as means ± SE. MI, myocardial infarction; IVSTd, intraventricular septal thickness in diastole; SV, stroke volume; CO, cardiac output; EF, ejection fraction; FS, fractional shortening; ANOVA, two-way analysis of variance. ^a p < 0.05 vs. wild-type MI, wild-type sham, Nedd4-2 C2-knockout sham; ^b p < 0.05 vs. wild-type sham, Nedd4-2 C2-knockout sham.

UCG Measrements	Wild-Type	Nedd4-2 C2 −/−	Wild-Type	Nedd4-2 C2 −/−	p
	MI	MI	Sham	Sham
	(n = 4)	(n = 4)	(n = 4)	(n = 4)	(ANOVA)
Week 0
IVSTd (mm)	0.73 ± 0.02	0.72 ± 0.02	0.72 ± 0.02	0.75 ± 0.01	0.5464
SV (μL)	44.59 ± 3.69	31.67 ± 1.51 a	45.80 ± 2.38	41.88 ± 1.18	0.0002
CO (mL/min)	22.81 ± 2.09	16.22 ± 0.75 a	22.40 ± 1.28	20.97 ± 0.62	0.0017
EF (%)	63.57 ± 1.84	67.99 ± 1.17	68.25 ± 1.52	66.67 ± 1.18	0.1427
FS (%)	29.00 ± 1.15	31.76 ± 0.81	32.16 ± 1.07	31.14 ± 0.87	0.1860
Week 3
IVSTd (mm)	0.70 ± 0.03	0.69 ± 0.02 b	0.76 ± 0.01	0.75 ± 0.01	0.0327
SV (μL)	57.07 ± 4.85	51.09 ± 1.87	50.67 ± 4.20	49.50 ± 1.77	0.3844
CO (mL/min)	27.42 ± 2.26	25.29 ± 0.90	24.44 ± 0.89	24.95 ± 1.12	0.3852
EF (%)	69.16 ± 1.23	68.81 ± 1.09	67.99 ± 3.13	68.17 ± 1.14	0.9708
FS (%)	32.60 ± 0.86	32.44 ± 0.76	33.68 ± 0.58	32.00 ± 0.80	0.4587
Week 6
IVSTd (mm)	0.75 ± 0.02	0.74 ± 0.02	0.77 ± 0.02	0.77 ± 0.02	0.5427
SV (μL)	58.81 ± 5.38	48.68 ± 1.62	54.80 ± 2.38	58.17 ± 2.69	0.1224
CO (mL/min)	29.93 ± 2.86	24.33 ± 0.66	27.05 ± 1.22	28.37 ± 1.39	0.1350
EF (%)	69.12 ± 1.11	70.45 ± 0.89	70.00 ± 0.89	69.86 ± 0.99	0.8338
FS (%)	32.63 ± 0.77	33.39 ± 0.63	33.35 ± 0.66	33.20 ± 0.73	0.8751