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. 2017 Jun 20;18(6):1316. doi: 10.3390/ijms18061316

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Simplified model comparing the outcomes of activated and rapidly desensitized mast cells. Resting mast cells (1) sensitizes with antigen-specific IgE bound to their high affinity IgE recepors (FcεRI) on cell surface (2) A: following the crosslinking of IgE/FcεRI receptors with an optimal dose of antigen leads to calcium flux (3–4), degranulation with release of the preformed mediators (5), early de novo synthesis of lipid mediators (6), and late cytokines/chemokines production(7). B: following administrating of suboptimal 11 doses to complete the same optimal dose as in A (activation) (3); leads to membrane rearrangements of receptors which impairs Ag/IgE/FcεRI complexes internalization and prevents all the hallmarks of MCs activation (red cross) such as calcium flux, degranulation, lipid mediators, and cytokine production.