Figure 2.

Effect of WIN 55212-2 administration during adolescence on pre-pulse inhibition after cocaine withdrawal in adulthood. Over PND 34–47 (adolescence), mice (n = 10 per group) were pre-treated with physiological saline (Sal) or WIN 55212-2 (WIN 0.5 mg/kg given once daily). In adulthood (21 days later) they were treated with Sal or cocaine (Coca) in three daily injections separated by a 60-min interval according to the ensuing regime: 5 mg/kg on PND 68 and 69, 15 mg/kg from PND 70 to 72, a two-day abstinence period, and 25 mg/kg from PND 75 to 79. Animals were tested on PND 81. Bars depict mean ± SEM of percentage of the pre-pulse inhibition response for trials with a pre-pulse of 75 dB with inter-stimulus intervals of 100 ms, and a pulse of 120 dB for all groups (** p < 0.01 significant differences between Sal and WIN pre-treated mice).