Figure 3.

Effect of WIN 55212-2 administration during adolescence on novel object recognition after cocaine withdrawal in adulthood. Over PND 34–47 (adolescence) mice (n = 10 per group) were pre-treated with Sal or WIN (0.5 mg/kg given once daily). In adulthood (21 days later) they were treated with Sal or Coca in three daily injections separated by a 60-min interval according to the ensuing regime: 5 mg/kg on PND 68 and 69, 15 mg/kg from PND 70 to 72, a two-day abstinence period, and 25 mg/kg from PND 75 to 79. Animals were tested on PND 82. Bars depict mean ± SEM of the Discrimination Index (DI) for all groups (* p < 0.05 significantly different from the Sal–Sal group).