Table 2.

Summary of the experimental design.

	Treatment					Behavioral Testing
PND	34–47	48–67	68–69	70–72	75–79	80	81	82	83
Group	SAL	-	SAL	SAL	SAL				TST
	SAL		COCA 5	COCA 15	COCA 25	OF	PPI	OR
	WIN		SAL	SAL	SAL	PPI	OR	EPM
	WIN		COCA 5	COCA 15	COCA 25

PND = Postnatal day; WIN = WIN 55212-2 (0.5 mg/kg) injected once a day during 14 consecutive days; COCA = cocaine given for three daily injections separated by a 60 min interval by the ensuing regime: 5 mg/kg on PND 68 and 69, 15 mg/kg on PND 70, 71 and 72, a 2 days abstinence period, and 25 mg/kg on PND 75, 76, 77, 78 and 79; SAL = saline (NaCl 0.9% w/v) given at the same treatment conditions as WIN and cocaine depending on the group. The experimental groups constituted were: Sal-Sal, WIN-Sal, Sal-Coca, and WIN-Coca. Behavioral testing began on PND 80. OF = open field, PPI = prepulse inhibition, OR = object recognition, EPM = elevated plus maze, TST = tail suspension test. For more details see the Materials and Methods section.