Table 2.

Results of a MCMC generalized linear mixed model from GS:SFHS predicting Odds-Ratios of MDD status, beta-coefficients for psychological distress (GHQ), P-value, upper and lower 95% confidence intervals and the Deviance Information Criterion AND results of a logistic regression from UK Biobank predicting Odds-Ratios for MDD status, beta-coefficients for psychological distress (PHQ), P-value, upper and lower 95% confidence intervals, the Akaike Information Criterion and adjusted R² value for the model.

Sample	Outcome	Variables	Odds-Ratio	β	Lower 95% CIs	Upper 95% CIs	P-value	DIC	AIC	R2
GS:SFHS	MDD	Age	1.00	–	0.99	1.01	9.71 × 10−2	12,561.35	–	–
		Sex (F)	1.71	–	1.48	1.97	< 1.00 × 10−4
		Neuroticism	3.71	–	3.37	4.12	< 1.00 × 10−4
		g	1.14	–	1.07	1.20	< 1.00 × 10−4
		Neuroticism*g	1.03	–	0.98	1.08	0.32
UK Biobank	MDD	Age	0.98	–	0.99	0.99	< 2.00 × 10−16	–	98,785	–
		Sex (F)	1.34	–	1.32	1.36	< 2.00 × 10−16
		Neuroticism	2.40	–	2.36	2.44	< 2.00 × 10−16
		g	1.06	–	1.04	1.07	5.08 × 10−14
		Neuroticism*g	0.96	–	0.95	0.98	< 1.09 × 10−7
GS:SFHS	GHQ	Age	–	0.00	−0.00	0.00	0.59	47,873.87	–	–
		Sex (F)	–	0.04	0.02	0.07	2.63 × 10−3
		Neuroticism	–	0.50	0.49	0.52	< 1.00 × 10−4
		g	–	−0.04	−0.05	−0.03	< 1.00 × 10−4
		Neuroticism*g	–	−0.05	−0.06	−0.04	< 1.00 × 10−4
UK Biobank	PHQ	Age	–	−0.02	−0.02	−0.01	< 2.00 × 10−16	–	–	0.2976
		Sex (F)	–	−0.02	−0.02	−0.01	1.57 × 10−8
		Neuroticism	–	0.51	0.51	0.52	< 2.00 × 10−16
		g	–	−0.05	−0.06	−0.05	< 2.00 × 10−16
		Neuroticism*g	–	−0.02	−0.03	−0.02	< 2.00 × 10−16

MCMC: Markov Chain Monte Carlo; GS:SFHS: Generation Scotland: the Scottish Family Health Study; GHQ: General Health Questionnaire; DIC: Deviance Information Criterion; g: General Intelligence; MDD: major depressive disorder; PHQ: Patient Health Questionnaire; AIC: Akaike Information Criterion.