Skip to main content
. 2017 Jun 7;106(1):263–275. doi: 10.3945/ajcn.116.150094

FIGURE 3.

FIGURE 3

HRs of incident T2D per A allele of rs10423928 (GIPR) by tertiles of macronutrient intake: comparison between Sonestedt et al. (41) and EPIC-InterAct. (A and B) HRs from Sonestedt et al. (41) (top) and pooled HRs from EPIC-InterAct (bottom) for both total carbohydrate intake (A) and total fat intake (B). Sonestedt et al. (41) adjusted for age, sex, physical activity, education, smoking status, sex-specific alcohol categories, season, TEI, method, and BMI. EPIC-InterAct replication adjusted for age (equal to the underlying time scale), sex, center, physical activity, education, smoking status, sex-specific alcohol categories, season, TEI, and BMI. P-interaction values for EPIC-InterAct were estimated by treating macronutrients and rs10423928 as continuous variables. Heterogeneity between countries was not significant in the EPIC-InterAct study (I2 = 17% and 19% in panels A and B, respectively). The total sample size for the EPIC-InterAct analysis was 21,148. Multiplicative interaction analysis was performed with Prentice-weighted Cox regression. EPIC, European Prospective Investigation into Cancer; GIPR, gastric inhibitory polypeptide receptor; TEI, total energy intake; T2D, type 2 diabetes.