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Molecular mechanism of glutamoptosis. During glutamoptosis, the activation of MTORC1 by αKG production through glutaminolysis (and perhaps also by other inputs from glutamine) induces the autophagy-dependent accumulation of SQSTM1/p62. In the absence of other amino acids, SQSTM1/p62 induces CASP8 cleavage in a BAX-dependent manner, leading to cell death.
