Table 4.

Reductive amination of acetophenone derivatives employing AmDHs

Entry	No.	Enzyme	Enzyme concentration [µM]	Time [h]	Conversion substrate [%]	ee% (R)
1	14a	Ch1-AmDH	130	48	9	>99
2	15a	Ch1-AmDH	50	48	39	>99
3	16a	Ch1-AmDH	130	48	34	>99
4	17a	Ch1-AmDH	130	48	22	>99
5	18a	Rs-PhAmDH	100	48	33	>99
6	19a	Ch1-AmDH	130	48	43	>99

Reaction conditions: 0.5 mL, 50 mM substrate, 30–130 µM enzyme, ammonium formate buffer (1.005 M, pH 8.5), 14 µM Cb-FDH.