Table 2.
Serum phosphorus, corrected calcium, intact-parathyroid hormone (PTH) levels, protein catabolic rate and Kt/V at each time-point
| PA21 750-mg group | PA21 1500-mg group | PA21 2250-mg group | PA21 3000-mg group | Placebo group | |
|---|---|---|---|---|---|
| Serum phosphorus level, mg/dL, mean ± SD (N) | |||||
| Week-3 | 5.71 ± 1.22 (39) |
5.75 ± 1.08 (35) |
5.65 ± 0.93 (33) |
5.33 ± 1.03 (34) |
5.58 ± 1.08 (37) |
| Week 0 | 7.36 ± 1.18 (39) |
7.69 ± 1.32 (35) |
7.42 ± 0.87 (33) |
7.57 ± 1.33 (34) |
7.26 ± 1.35 (37) |
| End of treatment | 5.57 ± 1.58 (39) |
4.99 ± 1.19 (35) |
4.27 ± 1.14 (33) |
3.74 ± 1.17 (34) |
7.50 ± 1.72 (37) |
| Change from Week 0 to end of treatment | −1.79 ± 1.40 (39) |
−2.70 ± 1.30 (35) |
−3.15 ± 1.36 (33) |
−3.84 ± 1.59 (34) |
0.24 ± 1.22 (37) |
| Corrected serum calcium level, mg/dL, mean ± SD (N) | |||||
| Week-3 | 8.83 ± 0.50 (39) |
8.99 ± 0.59 (35) |
8.97 ± 0.51 (33) |
9.06 ± 0.67 (34) |
8.85 ± 0.64 (37) |
| Week 0 | 8.49 ± 0.46 (39) |
8.65 ± 0.52 (35) |
8.59 ± 0.66 (33) |
8.69 ± 0.52 (34) |
8.58 ± 0.61 (37) |
| End of treatment | 8.69 ± 0.49 (39) |
8.81 ± 0.49 (35) |
8.97 ± 0.58 (33) |
9.07 ± 0.65 (34) |
8.49 ± 0.63 (37) |
| Change from Week 0 to end of treatment | 0.20 ± 0.34 (39) |
0.16 ± 0.33 (35) |
0.38 ± 0.44 (33) |
0.38 ± 0.39 (34) |
−0.09 ± 0.31 (37) |
| Serum intact-PTH level, pg/mL, mean ± SD (N) | |||||
| Week-3 | 198.5 ± 147.9 (39) |
187.7 ± 134.0 (35) |
249.8 ± 186.7 (33) |
169.3 ± 95.4 (34) |
195.4 ± 97.5 (37) |
| Week 0 | 277.9 ± 148.9 (39) |
262.1 ± 139.7 (35) |
345.0 ± 176.1 (33) |
262.8 ± 143.3 (34) |
282.4 ± 140.5 (37) |
| End of treatment | 242.7 ± 159.0 (39) |
221.2 ± 141.3 (34) |
261.7 ± 168.1 (31) |
173.4 ± 96.6 (31) |
303.9 ± 170.1 (37) |
| Change from Week 0 to end of treatment | −35.2 ± 89.8 (39) |
−45.6 ± 79.2 (34) |
−97.0 ± 92.7 (31) |
−86.5 ± 104.0 (31) |
21.5 ± 82.5 (37) |
| Protein catabolic rate (G/kg/day), mean ± SD | |||||
| Week 0 | 0.939 ± 0.121 (39) |
1.000 ± 0.136 (35) |
0.973 ± 0.159 (33) |
0.936 ± 0.157 (34) |
0.951 ± 0.166 (37) |
| End of treatment | 0.926 ± 0.153 (38) |
0.954 ± 0.101 (33) |
0.892 ± 0.142 (33) |
0.831 ± 0.182 (33) |
0.931 ± 0.159 (37) |
| Kt/V, mean ± SD | |||||
| Week 0 | 1.419 ± 0.292 (39) |
1.471 ± 0.298 (35) |
1.478 ± 0.300 (33) |
1.499 ± 0.292 (34) |
1.430 ± 0.247 (37) |
| End of treatment | 1.438 ± 0.323 (38) |
1.452 ± 0.285 (33) |
1.464 ± 0.277 (33) |
1.484 ± 0.285 (33) |
1.429 ± 0.254 (37) |