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. 2004 Dec 23;24(3):464–472. doi: 10.1038/sj.emboj.7600537

Figure 5.

Figure 5

Possible functional relationship between rhomboids and derlins. (A) Alignment of TMD2 of a variety of rhomboids and derlins; the conserved WR motif and hydroxyl residue are highlighted and residues conserved in rhomboids are bold. The species and GenBank accession numbers are: human (Hs) RHBDL2 (AAM95697) and Derlin-1 (NP_077271); D. melanogaster (Dm) Rho-1 (AAF47496) and Derlin-1 (NP_608632); C. elegans (Ce) ROM-1 (AAA91218) and Derlin-1 (NP_492721); E. coli (Ec) GlpG (BAB37690); B. subtilis (Bs) YqgP (NP_390367). (B) Topology model of human RHBDL2 compared with Derlin-1. The conserved WR and the hydroxyl residue (OH) in TMD2 are highlighted; the proposed rhomboid catalytic dyad residues (S and H) are indicated.