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. 2017 Jun 9;57(1):156–165. doi: 10.1007/s12020-017-1316-3

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Median a mUFC, b serum cortisol and c ACTH levels from baseline up to month 60. Error bars show 95% distribution-free confidence limits for median values. Numbers of patients with evaluable measurements are shown beneath each time point for the overall population. Dashed lines represent ULN for UFC (145 nmol/24 h) and ACTH (10 pmol/l). Data for the overall population (n = 162) have previously been reported up to month 12 [7] and month 24 [8]