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Amsterdam II criteria
| There should be at least three relatives with a Lynch/HNPCC-associated cancer (cancer of the colorectum, endometrium, small bowel, ureter or renal pelvis) and… |
| One should be a first-degree relative to the other two At least two successive generations should be affected At least one should be diagnosed before age 50 Familial adenomatous polyposis should be excluded Tumors should be verified by pathological examination |
Vasen et al. [8]
