Table 1.
The changes in intracellular primary endo-metabolites
| Metabolite | Percentage difference | Relative standard deviation (%) | ||||
|---|---|---|---|---|---|---|
| A. pal vs. F. oxy | A. pal vs. G. can | F. oxy vs. G. can | A. pal | F. oxy | G. can | |
| Leucine | −20.6* | 44.3* | 63.5* | 13.0 | 11.2 | 15.0 |
| Valine | −28.0* | −18.0 | 10.2 | 14.5 | 10.1 | 15.8 |
| Isoleucine | −29.2* | 13.0 | 41.8* | 13.1 | 10.1 | 14.4 |
| Isobutyrate | −75.8* | −47.4* | 31.2* | 7.3 | 8.1 | 10.2 |
| 3-Methyl-2-oxovalerate | −46.5* | −83.0* | −40.3* | 3.6 | 11.8 | 11.5 |
| Propylene glycol | −147.3* | −5.6 | 144.6* | 5.0 | 12.4 | 8.2 |
| Ethanol | −171.8* | −4.4 | 170.6* | 24.6 | 30.2 | 14.9 |
| Lactate | 1.0 | 3.9 | 2.8 | 5.8 | 11.7 | 14.0 |
| Alanine | −74.2* | −77.1* | −3.4 | 8.9 | 11.7 | 9.3 |
| Arginine | −17.8* | −26.7* | −9.0 | 5.0 | 10.8 | 10.2 |
| Lysine | −26.7* | −62.2* | −37.0* | 9.9 | 10.8 | 11.0 |
| Acetate | −75.0* | −51.4* | 26.2* | 9.7 | 10.0 | 15.8 |
| Proline | 7.1 | −32.2* | −39.1* | 4.9 | 10.3 | 11.1 |
| Methionine | −9.8 | −26.4* | −16.7 | 8.5 | 11.6 | 12.5 |
| 4-Aminobutyrate | −66.1* | 82.1* | 130.5* | 6.1 | 10.0 | 9.2 |
| Glutamate | −9.8 | −92.7* | −84.8* | 9.0 | 13.1 | 9.9 |
| Pyruvate | −31.0* | −66.8* | −37.7* | 5.4 | 10.7 | 6.9 |
| Succinate | −61.5* | −19.5* | 43.2* | 5.4 | 11.8 | 8.8 |
| Glutamine | 5.7 | −81.7* | −86.4* | 3.7 | 11.5 | 8.3 |
| Citrate | 4.4 | −97.3* | −100.6* | 4.2 | 12.2 | 7.1 |
| 2-Oxoisocaproate | −5.6 | −46.1* | −40.8* | 5.5 | 13.5 | 8.0 |
| Malate | −36.4* | −46.7* | −10.7 | 5.2 | 14.7 | 7.9 |
| Aspartate | −27.2* | 23.0* | 49.4* | 8.9 | 16.9 | 10.8 |
| Asparagine | 12.5* | −7.5 | −19.9* | 6.1 | 12.2 | 8.9 |
| Creatine | −6.2* | −67.0* | −61.4* | 40.7 | 11.1 | 9.6 |
| Malonate | 57.9* | 28.9* | −30.2* | 5.1 | 13.0 | 8.4 |
| Choline | 18.8 | −3.9* | −22.6 | 5.0 | 18.6 | 17.9 |
| sn-Glycero-3-phosphocholine | 32.2* | 6.3 | −26.0* | 6.8 | 10.1 | 9.0 |
| myo-Inositol | 33.2* | −0.1 | −33.2* | 5.1 | 35.9 | 7.6 |
| Glycerol | 74.7* | 116.3* | 53.1* | 6.9 | 34.1 | 9.0 |
| Glucitol | 55.3* | 65.0* | 10.7 | 6.1 | 22.9 | 7.0 |
| Mannitol | −5.4 | 106.3* | 110.1* | 6.9 | 9.6 | 8.8 |
| Betaine | 18.6* | 26.5* | 8.0 | 7.2 | 7.4 | 9.4 |
| Threonine | −19.5* | −21.6* | −2.2 | 8.7 | 8.2 | 11.6 |
| Xylose | −80.6* | 44.8* | 115.0* | 10.2 | 24.6 | 6.4 |
| Glucose | 68.3* | 9.9 | −59.4* | 8.2 | 6.6 | 15.8 |
| Glucose-1-phosphate | −61.3* | −79.0* | −20.1 | 13.0 | 21.0 | 11.7 |
| Uracil | −50.3* | −63.5* | −14.3 | 21.0 | 6.9 | 15.9 |
| Guanosine | −44.0* | 45.3* | 85.0* | 12.9 | 10.0 | 10.4 |
| Fumarate | −33.3* | −73.6* | −43.0* | 15.6 | 9.6 | 12.9 |
| Tyrosine | −15.7 | −15.4* | 0.3 | 12.6 | 6.5 | 9.5 |
| Histidine | −32.9* | −73.7* | −43.4* | 12.0 | 17.6 | 9.1 |
| Phenylalanine | −22.4* | 5.5 | 27.9* | 10.9 | 8.1 | 11.0 |
| Tryptophan | −30.7* | −22.8* | 8.0 | 16.0 | 8.1 | 7.8 |
| Xanthine | −85.3* | −123.8* | −52.3* | 13.6 | 23.7 | 20.4 |
| Unk1 | −121.7* | −5.8 | 118.0* | 17.6 | 17.1 | 11.6 |
| Unk2 | −0.8 | 6.2 | 7.0 | 12.0 | 10.9 | 17.6 |
| Unk3 | −135.1* | −130.8* | 7.8 | 21.3 | 11.4 | 13.6 |
| Unk4 | −55.4* | 41.9* | 92.0* | 13.5 | 10.6 | 12.4 |
| Unk5 | 171.8* | 112.7* | −114.5* | 14.9 | 50.1 | 159.5 |
| Unk6 | −106.7* | 0.6 | 107.1* | 29.7 | 45.7 | 35.5 |
The percentage difference was calculated based on the average values of relative signal integrals in each group. The calculations were made from left to right
*p < 0.01 using the Mann–Whitney–Wilcoxon test