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. 2017 Mar 22;134(1):45–64. doi: 10.1007/s00401-017-1696-8

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 7 — Iron and zinc in shadow plaques (case 14 in Fig. 1a). The shadow plaques (asterisks) are seen as a milder immunoreactivity for myelin proteins (PLP), and b pale Luxol fast blue staining (LFB/PAS); c Fe accumulates in one (black asterisk in a and b) of the two shadow plaques, but not the other one (white asterisk in a and b) (XFI); d The modified Turnbull stain shows a similar iron distribution (Fe histochemistry); e Zn is lost in the demyelinated lesion and shadow plaques (XFI); f The overlay of Fe and Zn shows the Fe accumulation in one of the two shadow plaques (XFI); g Higher magnification of the iron-accumulating (black asterisk in a and b) shadow plaque (Lfb/PAS); Oligodendrocytes with large nuclei are h positive for iron (Fe histochemistry), and i immunoreactive for H-ferritin (FTH) and L-ferritin (inset; FTL); j Higher magnification of the iron-poor (white asterisk in a and b) shadow plaque (Lfb/PAS); k Oligodendrocytes with normal sized nuclei in the iron-poor remyelinated lesion are immunoreactive for H ferritin (FTH) and L ferritin (inset; FTL); Scale bars a–f 3 mm; Scale bars g, j 500 μm; Scale bars h, i, k 20 μm; Color scales c, e represent the normalized total Kα fluorescence counts, proportional to total metal present, from blue (lowest) to red (highest); Color scale f represents the overlay of the normalized total Fe and Zn Kα fluorescence counts, proportional to total metal present, from blue (Zn) to red (Fe)