Fig. 9.

Differential involvement of immune effector mechanisms in perivascular type 2 and subpial type 3 cortical demyelination. Whereas subpial cortical demyelination occurs in the absence of an adaptive immune response, executed by the concerted action of pro-inflammatory cytokines, demyelinating antibodies, and CCR2⁺ monocytes, activated encephalitogenic T cells and NK cells substantially amplify perivascular cortical demyelination