TABLE 4.
Risk of cancer when family members were diagnosed with histology-specific lung cancer and risk of histology-specific lung cancer when family members were diagnosed with discordant cancer
| Cancer site and histological type | Negative family history | One lung cancer case in the family | At least two lung cancer cases in the family | Trend test p-value | ||
| Cases | RR (95% CI) | Cases | RR (95% CI) | |||
| Risk of discordant cancer | ||||||
| Anus | ||||||
| Adenocarcinoma | 1062 | 26 | 1.60# (1.08–2.36) | 0 | 0.0284¶ | |
| SCC | 1067 | 21 | 1.27 (0.84–1.94) | 0 | 0.2732 | |
| Small cell | 1083 | 5 | 1.21 (0.51–2.84) | 0 | 0.6734 | |
| Large cell | 1085 | 3 | 0.71 (0.24–2.14) | 0 | 0.5231 | |
| Connective tissue | ||||||
| Adenocarcinoma | 3697 | 71 | 1.48# (1.15–1.91) | 2 | 3.68 (0.82–16.61) | 0.0022¶ |
| SCC | 3730 | 40 | 0.89 (0.62–1.30) | 0 | 0.5455 | |
| Small cell | 3756 | 14 | 1.12 (0.64–1.94) | 0 | 0.6982 | |
| Large cell | 3758 | 12 | 0.93 (0.51–1.73) | 0 | 0.8255 | |
| Risk of lung cancer | ||||||
| Anus | ||||||
| Adenocarcinoma | 9660 | 27 | 1.77# (1.10–2.84) | 0 | 0.0307¶ | |
| SCC | 4040 | 6 | 0.95 (0.35- 2.62) | 0 | 0.9230 | |
| Small cell | 2534 | 4 | 1.00 (0.32–3.11) | 0 | 0.9986 | |
| Large cell | 3005 | 7 | 1.49 (0.45–4.88) | 0 | 0.5399 | |
| Connective tissue | ||||||
| Adenocarcinoma | 9619 | 68 | 1.40# (1.01–1.94) | 0 | 0.0575 | |
| SCC | 4027 | 19 | 0.94 (0.54–1.64) | 0 | 0.8300 | |
| Small cell | 2518 | 20 | 1.58# (1.04–2.40) | 0 | 0.0482¶ | |
| Large cell | 2989 | 23 | 1.53# (1.02–2.29) | 0 | 0.0542 | |
RR: relative risk; SCC: squamous cell carcinoma. #: significantly increased RR at the two-sided 5% level; ¶: statistically significant.