Table 2.
Molecular response (IWG-MRT/ELN criteria)a
Ruxolitinib-randomized (n = 102) | Ruxolitinib crossover (n = 94) | BAT (n = 85) | |
---|---|---|---|
CMR, n (%) | 2 (2.0) | 1 (1.1) | 0 |
Median time to CMR (weeks) | 143.4 | 123.0 | N/A |
PMR, n (%) | 33 (32.4) | 20 (21.3) | 1 (1.2) |
Median time to PMR (weeks) | 112.0 | 91.9 | 32.0 |
BAT best available therapy, CMR complete molecular response, IWG-MRT/ELN International Working Group–Myeloproliferative Neoplasms Research and Treatment/European LeukemiaNet, N/A not applicable, PMR partial molecular response
aAmong patients with a positive JAK2 p.V617F mutation at baseline and ≥1 postbaseline assessment of allele burden