Table 1.
Recent haemovigilance data on transfusion-transmitted infection
| Country | Year | Infection type | Number of incidents | Implicated blood components, where known (number of cases) | Causative agents, where known (number of recipients) | Frequency over reporting period | Overall frequency of adverse transfusion-related reactions |
|---|---|---|---|---|---|---|---|
| France [8] | 2015 | Bacterial | 2 Definite, 3 suspected | RBC (1), platelets (4) | Staphylococcus aureus (1—definite), Citrobacter koseri (1—definite); Staphylococcus epidermidis, non-specific Staphylococci | TTBI over 2015, per 105:1.31 (PC), 0.04 (RBC) | 241.7 per 105 units transfused |
| Viral | 2 Definite, 1 suspected | Platelets | HEV (3) | TTVI over 2015, per 105, 0.98 (PC) | |||
| Germany [9] | 2013–2014 | Bacterial | 11 Confirmed | RBC (5), platelets (6) | Various—from Staphylococcus to Klebsiella | Reporting frequency of TTBI for transfused units over 2013–2014, per 106:7.75 (RBC), 0.97 (PC) and 1.67 (FFP) TTBI (total) over 2013–2014 per 106: [5] 0.65 (RBC), [6] 6.19 (PC), [6] 0 (FFP) | No information given |
| Viral | 5 Confirmed | RBC (1), platelets (4) | HEV (5) | Reporting frequency of TTVI for transfused units over 2013–2014, per 106: 7.75 (RBC), 0.97 (PC) and 1.67 (FFP) TTVI (total) over 2013–2014 per 106: [1] 0.13 (RBC), [4] 4.12 (PC), none (FFP) | |||
| Italy [10] | 2014 | Bacterial only | 5 | RBC (3), platelets (2) | Serratia marcescens; not specified | Adverse reaction requiring resuscitation procedures, 1 per 1649 transfused units. Adverse reaction inducing fatal consequences, 1 per 397,965 transfused units | |
| Spain [11] | 2015 | Bacterial | 3 Definite, 4 suspected | Platelets | Serratia marcescens (3), Corynebacterium spp. (2) and Staphylococcus capitis (2) | No information given | No information given |
| Viral | 1 | RBC | HEV | ||||
| UK [12] | 2015 | Bacterial | 1 Definite, 1 possible, 3 indeterminate | Platelets (2—definite/possible) | Staphylococcus aureus (1) and Streptococcus agalactiae/Escherichia coli (1) | TTI over 2015 per 105: 1.6 | Total cases, 436.5 per 105 |
| Viral | 2 Definite, 3 investigations pending | Platelets (2—definite), cryoprecipitate | HEV (2—definite); HCV (2—pending), HEV (1—pending) | ||||
| USA [13] | 2010–2012 | Bacterial and protozoal | 6 Definite, 2 probable, 4 possible | Platelets (7), RBC (4), not specified (1) | Staphylococcus spp., Corynebacterium spp., Acinetobacter/Achromobacter spp., Babesia microti | TTI per 105: 0.3 (RBC), 1.8 (PC), 0 (plasma), 0 (cryoprecipitate) | All events, 239.5 per 105. Severe, life-threatening or fatal, 17.5 per 105 |
HCV hepatitis C virus, HEV hepatitis E virus, RBC red blood cells