Table 3.
Mean diffusion parameters according to patient outcome
| Parameters | Responders | Non-responders | p value |
| Baseline (n = 36) | |||
| ADC (×10−3mm2/s) | 0.92 ± 0.03 | 1.20 ± 0.02 | <0.01** |
| DDC (×10−3mm2/s) | 0.93 ± 0.04 | 1.25 ± 0.03 | <0.01** |
| α | 0.84 ± 0.02 | 0.81 ± 0.02 | 0.07 |
| D t (×10−3mm2/s) | 0.85 ± 0.05 | 1.02 ± 0.05 | 0.02* |
| ƒ (%) | 12.10 ± 2.02 | 10.32 ± 1.15 | 0.09 |
| Mid-treatment (n = 22) | |||
| Parameters | Responders (% change) | Non-responders (% change) | p value of %change |
| ADC (×10−3mm2/s) | 1.52 ± 0.32 (↑49 %) | 1.27 ± 0.18 (↑21 %) | 0.03* |
| DDC (×10−3mm2/s) | 1.51 ± 0.15 (↑43 %) | 1.40 ± 0.12 (↑32 %) | 0.04* |
| α | 0.91 ± 0.07 (↑7 %) | 0.86 ± 0.11 (↑5 %) | 0.68 |
| D t (×10−3mm2/s) | 1.30 ± 0.14 (↑36 %) | 1.28 ± 0.15 (↑23 %) | 0.14 |
| ƒ (%) | 8.48 ± 1.54 (↓29 %) | 10.53 ± 2.51 (↑5 %) | 0.05 |
Baseline and mid-treatment values of the various parameters (units × 10−3 mm2/s except where shown). Values in parenthesis are the percentage change. P values using a two-tailed independent t test compared between response groups. Significant statistics have p < 0.05, while highly significant statistics have p < 0.01 which includes a correction for multiple comparisons). Unless otherwise indicated, data represent mean values ± standard deviation (percentage change between pretreatment and mid-treatment values) of the mono-exponential (ADC), bi-exponential (D t, ƒ) and stretched-exponential (DDC, α) parameters
*Values show statistically significant differences
**Values show highly significant differences