Table 1.
Baseline, surgical, and histopathologic characteristics of 1701 patients treated with neoadjuvant chemotherapy followed by gastrectomy for cancer
| Characteristic | All (N = 1701) | <5 weeks (n = 895) | 5–8 weeks (n = 451) | >8 weeks (n = 140) | p | ||||
|---|---|---|---|---|---|---|---|---|---|
| n | % | n | (%) | n | (%) | n | (%) | ||
| Baseline characteristics | |||||||||
| Age, year, mean (±SD) | 62.6 | (±10.6) | 62.4 | (10.7) | 63.2 | (10.5) | 62.4 | (9.0) | 0.386 |
| Gender | 0.479 | ||||||||
| Male | 1064 | (63) | 548 | (59) | 287 | (31) | 92 | (10) | |
| Female | 637 | (37) | 347 | (62) | 164 | (29) | 48 | (9) | |
| Malignancy history | 0.934 | ||||||||
| No | 1546 | (91) | 814 | (60) | 409 | (30) | 126 | (9) | |
| Yes | 155 | (9) | 81 | (59) | 42 | (31) | 14 | (10) | |
| Tumor differentiation | 0.163 | ||||||||
| Good to moderate | 202 | (20) | 110 | (21) | 44 | (17) | 19 | (26) | |
| Poor to undifferentiated | 798 | (80) | 403 | (79) | 217 | (83) | 55 | (74) | |
| Missing | 701 | 382 | 190 | 66 | |||||
| cT stage | 0.399 | ||||||||
| T1 | 44 | (5) | 22 | (55) | 12 | (30) | 6 | (15) | |
| T2 | 439 | (50) | 235 | (56) | 138 | (33) | 45 | (11) | |
| T3 | 304 | (35) | 158 | (55) | 97 | (34) | 30 | (11) | |
| T4a | 88 | (10) | 33 | (45) | 26 | (36) | 14 | (19) | |
| Tx | 826 | 447 | 178 | 45 | |||||
| cN stage | 0.466 | ||||||||
| N0 | 951 | (65) | 504 | (58) | 277 | (32) | 82 | (10) | |
| N+ | 511 | (35) | 285 | (62) | 134 | (29) | 42 | (9) | |
| Nx | 239 | 106 | 40 | 16 | |||||
| Year of diagnosis | 0.268 | ||||||||
| 2006–2008 | 356 | (21) | 120 | (59) | 57 | (28) | 28 | (14) | |
| 2009–2011 | 616 | (36) | 339 | (61) | 170 | (30) | 49 | (9) | |
| 2012–2014 | 729 | (43) | 436 | (60) | 224 | (31) | 63 | (9) | |
| Referral status | <0.001 | ||||||||
| Diagnosis in treatment hospital | 1009 | (69) | 536 | (53) | 233 | (23) | 64 | (6) | |
| Diagnosis in other hospital | 445 | (31) | 211 | (47) | 144 | (32) | 53 | (12) | |
| Missing | 247 | 148 | 74 | 23 | |||||
| Treatment and histopathologic characteristics | |||||||||
| Surgical type | 0.687 | ||||||||
| Distal gastrectomy | 924 | (54) | 487 | (61) | 236 | (30) | 77 | (10) | |
| Total gastrectomy | 749 | (44) | 394 | (59) | 211 | (32) | 62 | (9) | |
| Multiorgan surgery | 28 | (2) | 14 | (74) | 4 | (21) | 1 | (5) | |
| Surgical approach | 0.679 | ||||||||
| Open | 1447 | (86) | 742 | (60) | 373 | (30) | 119 | (10) | |
| Laparoscopic | 230 | (14) | 141 | (62) | 69 | (30) | 18 | (8) | |
| Missing | 24 | 12 | 9 | 3 | |||||
| Radicality | 0.782 | ||||||||
| R0 | 1405 | (86) | 738 | (60) | 368 | (30) | 116 | (9) | |
| R1–2 | 239 | (15) | 129 | (61) | 66 | (31) | 17 | (8) | |
| Missing | 57 | 28 | 17 | 7 | |||||
| ypT stage | <0.001 | ||||||||
| T0 | 112 | (7) | 56 | (57) | 37 | (37) | 6 | (6) | |
| T1 | 236 | (14) | 96 | (48) | 69 | (34) | 36 | (18) | |
| T2 | 256 | (15) | 142 | (62) | 67 | (29) | 20 | (9) | |
| T3 | 700 | (42) | 385 | (62) | 186 | (30) | 48 | (8) | |
| T4a | 309 | (19) | 162 | (62) | 73 | (28) | 25 | (10) | |
| T4b | 57 | (3) | 39 | (74) | 11 | (21) | 3 | (6) | |
| Tx | 31 | 15 | 8 | 2 | |||||
| ypN stage | 0.036 | ||||||||
| N0 | 805 | (47) | 387 | (55) | 234 | (33) | 80 | (11) | |
| N1 | 338 | (20) | 193 | (67) | 78 | (27) | 19 | (7) | |
| N2 | 274 | (16) | 147 | (63) | 64 | (28) | 21 | (9) | |
| N3 | 282 | (17) | 168 | (64) | 75 | (29) | 20 | (8) | |
| Nx | 2 | ||||||||
| ypM stage | 0.357 | ||||||||
| M0 | 1625 | (96) | 885 | (61) | 438 | (30) | 135 | (9) | |
| M1 | 76 | (5) | 40 | (69) | 13 | (22) | 5 | (9) | |
| Curative intent | 0.112 | ||||||||
| Yes | 1544 | (92) | 807 | (57) | 419 | (30) | 188 | (13) | |
| No | 127 | (8) | 74 | (62) | 24 | (20) | 21 | (18) | |
| Missing | 30 | 14 | 8 | 6 | |||||
| 90-day mortality | 69 | (4) | 40 | (4) | 12 | (3) | 7 | (5) | 0.223 |
| Adjuvant therapy | 0.009 | ||||||||
| No | 724 | (43) | 371 | (59) | 200 | (32) | 62 | (10) | |
| Chemotherapy | 783 | (46) | 429 | (64) | 185 | (27) | 61 | (9) | |
| Radiotherapy | 5 | (<1) | 2 | (50) | 0 | (0) | 2 | (50) | |
| Chemoradiation | 189 | (11) | 93 | (53) | 66 | (38) | 15 | (9) | |