Table 1.

Effect of enamel matrix proteins on the rate of proliferation of HGF-1 cells

EMP added, µg/mL	Cell index value, mean ± standard deviation
	Time of incubation
	12 h	24 h	48 h	P value
Control	2.1 ± 1.2	2.3 ± 1.2	2.6 ± 0.3	<0.05
EMD, 12.5	3.5 ± 0.2	4.0 ± 0.5	4.1 ± 0.1	<0.05
EMD, 25.0	3.3 ± 0.5	3.7 ± 0.4	4.9 ± 0.1	<0.01
EMD, 50.0	4.0 ± 0.3	4.3 ± 0.3	5.3 ± 0.3	<0.001
prAMEL, 12.5	2.4 ± 1.2	2.8 ± 1.1	2.6 ± 0.2	<0.05
prAMEL, 25.0	2.3 ± 1.2	2.7 ± 1.2	2.8 ± 0.3	<0.05
prAMEL, 50.0	2.5 ± 1.2	2.8 ± 1.2	3.0 ± 0.5	<0.05
TRAP, 12.5	2.0 ± 1.3	2.6 ± 1.3	2.8 ± 0.4	<0.05
TRAP, 25.0	1.9 ± 2.3	2.6 ± 1.3	2.8 ± 0.4	<0.05
TRAP, 50.0	2.2 ± 1.3	2.5 ± 1.3	2.9 ± 0.6	<0.05
P value	0.7	0.04	<0.0001

The cell index value monitored by the xCELLigence system. Results are from five repeats

EMP enamel matrix protein, EMD enamel matrix derivative, prAMEL porcine recombinant amelogenin, TRAP tyrosine-rich amelogenin peptide