Table 4. Clinical activity.

Parameter (n = 24)	Dose escalation (n = 8/12 evaluable)	Dose expansion (n = 4/6 evaluable)	“B” dose escalation (n = 6/6 evaluable)
Best ORR by RECIST
CR/PR	0	0	0
SD	3	2	4
PD	5	2	2
Best ORR by irRC
CR/PR	0	0	0
SD	6	2	3
PD	2	2	3
GIST patients only (n = 17)	n = 5/7 evaluable	4/6 evaluable	4/4 evaluable
Best ORR by Choi
CR/PR	3	1	3
SD	1	2	0
PD	1	1	1

Abbreviations: ORR, overall response rate; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.