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. Author manuscript; available in PMC: 2017 Jun 27.
Published in final edited form as: Free Radic Biol Med. 2016 Mar 2;94:185–194. doi: 10.1016/j.freeradbiomed.2016.02.036

Figure 6. Proposed model of how MnTE-2-PyP effects PAI-1 expression.

Figure 6

Without MnTE-2-PyP, the p300 binding complex can directly bind to the promoter region of human PAI-1 gene, acetylate the chromatin and promote PAI-1 gene transcription. In the presence of MnTE-2-PyP, with or without radiation, the p300 transcriptional complex no longer binds to the promoter region of human PAI-1 gene, histone acetylation is reduced and, thus, PAI-1 gene expression is down-regulated.