Table 3.

Association of test results the with the composite atherosclerotic cardiovascular disease (ASCVD) outcome

Variable	Unadjusted HR (95% CI)		Model 1 HR (95% CI)		Model 2 HR (95% CI)
	MESA	DHS	MESA	DHS	MESA	DHS
Continuous Test Results
ECG-LVH *	1.71 (1.33, 2.21)	2.76(1.67, 4.56)	1.24 (0.95, 1.61)	1.83 (1.07, 3.12)	1.14 (0.87, 1.48)	1.84 (1.08, 3.14)
Ln (CAC+1)	2.04 (1.87, 2.22)	2.17 (1.88, 2.50)	1.56 (1.41, 1.73)	1.43 (1.20, 1.72)	1.49 (1.34, 1.65)	1.43 (1.19, 1.72)
Ln (NT-proBNP)	1.73 (1.62, 1.85)	1.56 (1.27, 1.92)	1.45 (1.30, 1.61)	1.25 (1.01, 1.55)	1.29 (1.15, 1.43)	1.18 (0.95, 1.47)
Ln (hs-cTnT)	1.73 (1.62, 1.85)	1.74 (1.53, 1.97)	1.37 (1.25, 1.49)	1.16 (0.98, 1.38)	1.23 (1.12, 1.35)	1.11 (0.93, 1.34)
Ln (hs-CRP)	1.17 (1.08, 1.28)	1.19 (0.97, 1.47)	1.09 (0.99, 1.21)	0.97 (0.77, 1.22)	1.07 (0.97, 1.17)	0.93 (0.74, 1.18)
Categorical test results
ECG-LVH *	1.71 (1.33, 2.21)	2.45 (1.49, 4.02)	1.24 (0.95, 1.61)	1.69 (0.99, 2.87)	1.19 (0.92, 1.55)	1.88 (1.10, 3.20)
CAC > 10 U	3.87 (3.18, 4.72)	7.27 (4.87, 10.85)	2.17 (1.74, 2.70)	2.31 (1.44, 3.70)	2.09 (1.67, 2.60)	2.31 (1.44, 3.71)
NT-proBNP ≥100 pg/mL	2.44 (2.04, 2.92)	3.22 (2.10, 4.92)	1.69 (1.35, 2.11)	2.25 (1.38, 3.68)	1.55 (1.26, 1.91)	1.99 (1.19, 3.32)
hs-cTnT ≥ 5 ng/L	2.78 (2.31, 3.36)	4.20 (2.87, 6.17)	1.40 (1.13, 1.74)	1.43 (0.91, 2.25)	1.29 (1.04, 1.59)	1.23 (0.75, 2.02)
hs-CRP ≥ 3 mg/L	1.38 (1.16, 1.65)	1.54 (1.05, 2.25)	1.24 (1.02, 1.50)	1.12 (0.74, 1.69)	1.19 (0.98, 1.44)	1.10 (0.72, 1.70)

Model 1 is adjusted for age, sex, race, smoking status, diabetes, total cholesterol, HDL-cholesterol, systolic blood pressure and blood pressure medications, and statin use. Model 2 includes the components of model 1 and all 5 test results. The Hazard Ratio (HR) for continuous test results reflects a one standard deviation change in the Ln of the test result. N=486 events in MESA and 96 in DHS.

^*ECG-LVH was treated as a categorical variable in both analyses. Coefficients were determined separately for each model.