Table 4.

Change in risk prediction metrics with additional of test results to base models

	MESA				DHS
	C-statistic Base Model*	C-statistic Base Model + Test Results	Category free NRI	IDI	C-statistic Base Model*	C-statistic Base Model + Test Results	Category free NRI	IDI
Global CVD	0.743	0.786†	0.473 (0.383,0.563)	0.073 (0.063, 0.083)	0.832	0.850‡	0.261 (0.052,0.47)	0.024 (0.008, 0.04)
ASCVD	0.748	0.779†	0.394 (0.275,0.512)	0.042 (0.032, 0.052)	0.859	0.873‡	0.355 (0.129,0.581)	0.021 (0.001, 0.041)
CHD	0.749	0.794†	0.498 (0.357,0.638)	0.043 (0.031, 0.055)	0.865	0.889‡	0.585 (0.294,0.877)	0.058 (0.023, 0.093)
Heart Failure	0.786	0.847†	0.549 (0.407,0.692)	0.086 (0.064, 0.108)	0.840	0.871§	0.719 (0.381,0.989)	0.13 (0.042, 0.218)
All-Cause Mortality	0.746	0.789†	0.315 (0.199,0.431)	0.038 (0.03, 0.046)	0.817	0.829	0.061 (−0.516,0.638)	0.03 (0.005, 0.055)
Cardiovascular Mortality	0.822	0.840‡	0.438 (0.185,0.691)	0.05 (0.032, 0.068)	0.840	0.858	0.308 (−0.045,0.662)	0.012 (−0.01, 0.034)

^*Base model includes variables in the pooled cohort equations plus statin therapy. Global CVD models additionally include creatinine and heart failure models additionally include body mass index and creatinine. Coefficients were determined separately for each model.

^†p<0.001;

^‡p<0.01;

^§p<0.05 vs. base model