Table 2.
Treatment toxicity and complications
| Group 1 (n = 89) n (%) |
Group 2 (n = 72) n (%) |
P value | |
|---|---|---|---|
| Completed nCRT | 71 (79.8) | 58 (80.6) | 0.902a |
| Hematologic toxicity | 0.068a | ||
| Thrombocytopenia–overall | |||
| Not applicable | 26 (29.2) | 28 (38.9) | |
| Grade 1 | 54 (60.7) | 43 (59.7) | |
| Grade 2 | 8 (9.0) | 1 (1.4) | |
| Grade 3 | 1 (1.1) | 0 (0.0) | |
| Leukopenia–overall | 0.338a | ||
| Not applicable | 15 (16.9) | 20 (27.8) | |
| Grade 1 | 34 (38.2) | 21 (29.2) | |
| Grade 2 | 26 (29.2) | 19 (26.4) | |
| Grade 3 | 13 (14.6) | 12 (16.7) | |
| Grade 4 | 1 (1.1) | 0 (0.0) | |
| Blood transfusion | 0.417a | ||
| 0 | 87 (97.8) | 67 (93.1) | |
| 1 | 0 (0.0) | 1 (1.4) | |
| 2 | 1 (1.1) | 1 (1.4) | |
| 3 | 1 (1.1) | 2 (2.8) | |
| 4 | 0 (0.0) | 1 (1.4) | |
| Other nCRT complications (grade ≥ 3) | |||
| Anemia | 0 (0.0) | 0 (0.0) | NAa |
| Bleeding | 0 (0.0) | 1 (1.4) | 0.203a |
| Nausea | 3 (3.4) | 4 (5.6) | 0.501a |
| Fatigue | 1 (1.1) | 1 (1.4) | 0.880a |
| Neurotoxic | 0 (0.0) | 2 (2.8) | 0.071a |
| Diarrhea | 0 (0.0) | 1 (1.4) | 0.203a |
| Esophagitis | 2 (2.2) | 5 (6.9) | 0.144a |
| Grade ≥ 3 or blood transfusion | 22 (24.7) | 26 (36.1) | 0.117a |
| Postoperative complications | |||
| Pulmonary (all grades)b | 49 (55.1) | 38 (52.8) | 0.773a |
| Pneumonia | 41 (46.1) | 28 (38.9) | 0.360a |
| Respiratory insufficiency | 19 (21.3) | 13 (18.1) | 0.602a |
| Pulmonary embolism | 2 (2.2) | 0 (0.0) | 0.122a |
| Cardiac (all grades)c | 26 (29.2) | 22 (30.6) | 0.835a |
| Arrhythmia | 25 (28.1) | 22 (30.6) | 0.732a |
| Myocardial infarction | 1 (1.4) | 0 (0.0) | 0.273a |
| Sepsis | 8 (9.0) | 6 (8.3) | 0.883a |
| Postoperative bleeding | 2 (2.2) | 1 (1.4) | 0.678a |
| Chylothorax | 11 (12.4) | 3 (4.2) | 0.057a |
| Cardiac arrest | 2 (2.2) | 3 (4.2) | 0.486a |
| Esophageal anastomotic leak | 8 (9.0) | 12 (16.7) | 0.143a |
| Renal failure | 2 (2.2) | 4 (5.6) | 0.276a |
| IIeus | 6 (6.7) | 2 (2.8) | 0.237a |
| All patients with complications (all grades) | 60 (67.4) | 50 (69.4) | 0.783a |
| Postoperative mortality | |||
| 30-day mortality | 2 (2.2) | 3 (4.2) | 0.486a |
| 90-day mortality | 6 (6.7) | 7 (9.7) | 0.492a |
nCRT neoadjuvant chemoradiotherapy, NA not applicable
aLikelihood ratio
bPneumonia, atelectasis, respiratory insufficiency, acute respiratory distress syndrome, pleural effusion, pneumothorax and/or pulmonary embolism
cArrhythmia and/or myocardial infarction