Fig. 1.

a The effect of acute (1 h before locomotor activity testing) treatment on locomotor activity in mice. Data presented as mean ± S.E.M. activity counts over a 30-min test in 5-min periods. Significant changes were observed in the KET 20 mg/kg + CLZ 1 mg/kg group vs the control group (SAL), *p < 0.05, **p < 0.01, ***p < 0.0001. b The effect of sub-chronic treatment on locomotor activity in mice. Behavioural test of Locomotor Activity was made 24 h after last treatment. Data presented as mean ± S.E.M. activity counts over a 30-min test in 5-min periods. No significant difference between the groups was observed