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. 2017 Jun 27;15(6):e2001336. doi: 10.1371/journal.pbio.2001336

Fig 2. Cyclophilin 40 (CyP40) overexpression decreased sarkosyl-insoluble tau.

Fig 2

(A) Schematic depicting the timeline of rTg4510 tau pathology and experimental design. (B) Western blot comparing sarkosyl-insoluble and sarkosyl-soluble fractions from the hippocampi of adeno-associated virus serotype 9–green fluorescent protein (AAV9-GFP) (n = 8) and AAV9-CyP40 (n = 8) injected rTg4510 mice. Each lane indicates an individual transgenic mouse. (C) Quantification of the relative insoluble and soluble tau for AAV9-GFP and AAV9-CyP40 injected mice (unpaired t test, n = 8 for each group). The numerical data used in panel 2C can be found in S1 Data. GAPDH, glyceraldehyde 3-phosphate dehydrogenase; SEM, standard error of the mean.