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. 2005 Mar 1;115(3):765–773. doi: 10.1172/JCI200521948

Figure 2.

Figure 2

α-Defensin-1 inhibited HIV-1 primary isolates following viral entry. (A–C) Primary CD4+ T cells were infected with HIV-1 primary isolates using R5, X4, or X4R5 coreceptors. The names and tropisms of virus isolates are indicated, and viral genotypes are shown in parentheses. (D) As a control, cells were also infected with a laboratory-adapted strain, HIVIIIB. After a 2-hour viral inoculation, cells were washed and treated with α-defensin-1 at different concentrations. HIV-1 production was measured, and the levels of HIV-1 p24 at day 10 after infection are shown. P < 0.05, α-defensin-1–treated infected cells vs. nontreated controls. Data are mean ± SD of triplicate samples and represent 2 independent experiments.