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. 2005 Mar 1;115(3):765–773. doi: 10.1172/JCI200521948

Figure 6.

Figure 6

α-Defensin-1 and a PKC isoform–selective inhibitor, Go6976, blocked the HIV-1 life cycle at similar stages. (A) The effect of the PKCα and β inhibitor Go6976 on HIV-1 infection in primary CD4+ T cells was determined by a single-cycle infection assay. Cells infected with HIV-1HxB2–pseudotyped luciferase viruses were treated with Go6976 at different concentrations at 2 hours after infection. (B) The kinetics of the HIV-1 life cycle in primary CD4+ T cells in the presence of α-defensin-1 or Go6976 were studied as described in Figure 4. P < 0.05, inhibitor-treated cells vs. nontreated controls at different time points. Data are mean ± SD of triplicate samples and represent 3 independent experiments.