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. 2005 Mar 1;115(3):622–631. doi: 10.1172/JCI200522263

Figure 5.

Figure 5

Histologic changes in the articular cartilage and synovium of Prg4–/– mice. H&E-stained sagittal section through the tibia of 7-day-old heterozygous (A) and Prg4–/– (D) mice, 2-month-old heterozygous (B) and Prg4–/– (E) mice, and 9-month-old heterozygous (C) and Prg4–/– (F) mice (magnification in A–F, ×400). Note that flattened superficial zone chondrocytes are present in both the heterozygous and Prg4–/– cartilage of the 7-day-old mice (arrows) (A and D). Flattened superficial zone chondrocytes are present in both the 2-month old and 9-month old (B and C) heterozygous mice (arrow) but are lost in the 2-month-old and 9-month-old Prg4–/– mice (E and F). Also note the presence of a thick layer of weakly stained material at the cartilage surface (bracket) (E). (G–L) H&E-stained section of knee synovium from 15-day-old wild-type (G) and Prg4–/– (H) mice (magnification, ×400), 2-month-old heterozygous (I) and Prg4–/– (J) mice (magnification, ×400), and 6-month-old heterozygous (K) and Prg4–/– (L) mice (magnification, ×200). Note the progressive hyperplasia and thickening (brackets) of the intimal and subintimal layers in the Prg4–/– mice (H, J, and L).