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. Author manuscript; available in PMC: 2018 Apr 18.
Published in final edited form as: Angew Chem Int Ed Engl. 2017 Mar 28;56(17):4729–4733. doi: 10.1002/anie.201700103

Figure 2.

Figure 2

ACS-7 contributes to the biosynthesis of 4′-acylated ascarosides. a) Abundances of ascarosides in acs-7(tm6781) mutants relative to wildtype C. elegans. Error bars =standard error of three biological replicates. The variability in ascaroside biosynthesis in wildtype C. elegans is assessed in Figure S2. b) HPLC–MS (ESI−) ion chromatograms for icas#9 and osas#9 in wildtype, acs-7(tm6781) mutants, and acs-7(tm6781) mutants expressing gfp::acs-7. c) HPLC–MS (ESI−) ion chromatograms showing ACS-7-dependent formation of the adenylates of N-succinyl octopamine and indole-3-carboxylic acid (also see Figure S4).