Table 1. Clinical characteristics of treatment groups.
Variables | Whole cohort N = 20 |
IVIG+ N = 11 |
IVIG- N = 9 |
P |
---|---|---|---|---|
At the time of transplant | ||||
Recipient | ||||
Female sex, N (%) | 8 (40) | 5 (45) | 3 (33) | 0.50 |
Age, years, mean (SD), range | 47 (± 15) (22–75) | 45 (± 17) (28–75) | 50 (± 15) (22–63) | 0.54 |
Initial nephropathy, N (%) | ||||
Glomerular | 8 (40) | 6 (55) | 2 (28) | 0.31 |
Genetic | 1 (5) | 1 (9) | 0 (0) | |
Other | 11 (55) | 4 (45) | 6 (66) | |
Dialysis, N (%) | 16 (80) | 10 (90) | 6 (66) | 1.00 |
Time, months, median (Q1-Q3) | 49 (33–57) | 51 (40–61) | 42 (21–89) | 0.67 |
Donor | ||||
Deceased, N (%) | 17 (85) | 9 (81) | 6 (66) | 1.00 |
Female sex, N (%) | 11 (55) | 6 (55) | 5 (55) | 1.00 |
Age, years, mean (SD) | 49 (±16) | 52 (±16) | 44 (±17) | 0.34 |
eGFR (ml/min/1,73m2), mean (SD) | 89 (±36) | 81 (±40) | 103 (±27) | 0.21 |
Proteinuria (g/l), median (Q1-Q3) | 0.14 (0.07–0.47) | 0.14 (0.11–0.68) | 0.06 (0.04–0.25) | 0.04 |
Cold ischemia time, hours, mean (SD) | 18 (±7) | 18 (±5) | 18 (±11) | 0.90 |
HLA mismatch | ||||
class I, mean (SD) | 3 (±1) | 3 (±1) | 3 (±1) | 1.00 |
class II, mean (SD) | 2 (±1) | 2 (±1) | 3 (±1) | 0.23 |
Anti-HLA antibodies, N (%) | 8 (40) | 5 (45) | 3 (33) | 0.32 |
Donor specific antibodies, N (%) | 0 (0) | 0 (0) | 0 (0) | . |
Immunosuppression | ||||
Induction, N (%) | 20 (100) | 11 (100) | 9 (100) | 1.00 |
Anti-thymocyte globulin, N (%) | 11 (55) | 7 (64) | 4 (43) | 0.63 |
Interleukin-2 receptor antibody, N (%) | 9 (45) | 4 (36) | 5 (57) | |
Post-transplant | ||||
Maintenance therapy | ||||
Steroids, N (%) | 20 (100) | 11 (100) | 9 (100) | 0.65 |
Calcineurin inhibitors, N (%) | 20 (100) | 11 (100) | 9 (100) | |
Cyclosporine, N (%) | 9 (45) | 4 (36) | 5 (55) | |
Tacrolimus, N (%) | 11 (55) | 7 (64) | 4 (44) | |
Mycophenolate mofetil, N (%) | 20 (100) | 11 (100) | 9(100) | |
Infectious diseases, N (%) | ||||
CMV viremia, N (%) | 2 (10) | 2 (18) | 0 (0) | 0.49 |
Before IVIG, N (%) | . | 1 (50) | . | |
BK virus viremia, N (%) | 2 (10) | 1 (9) | 1 (11) | 1.00 |
Before IVIG, N (%) | . | 1 (100) | . | |
Last follow-up | ||||
eGFR, ml/min/1.73m2, mean (SD) | 56 (±22) | 58 (±25) | 53 (±20) | 0.60 |
Allograft loss, N (%) | 0 (0) | 0 (0) | 0 (0) | . |
Death, N (%) | 0 (0) | 0 (0) | 0 (0) | . |