Figure 1.

Hits of high throughput in vitro drug screen of three MLS cell lines. List of 27 drugs with a reduction in cell viability of >50% in two or all three cell lines at a drug concentration of 100 nM. Strong inhibitory effect of the survivin inhibitor YM155 is observed in two out of three MLS cell lines. Also, a good response is observed to several conventional chemotherapeutics, like doxorubicin, gemcitabine, and paclitaxel. Per drug, four concentrations (1, 10, 100, and 1000 nM) are tested; green boxes correspond to a high cell viability (~100%) and red boxes to a loss of cell viability (~0%). For comparison, at the bottom, five compounds are randomly shown that did not meet the criteria.