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. 2017 Jun 24;10(4):546–554. doi: 10.1016/j.tranon.2017.05.007

Figure 4.

Figure 4

Effect of YM155 on apoptosis and cell cycle. YM155 does not cause PARP-dependent apoptosis but increases S-phase in two of the MLS cell lines. Western blot analysis for PARP and cleaved PARP expression in MLS cell lines (A). FACS cell cycle analysis of MLS cell lines treated with YM155 for 48 hours, measured in two independent experiments. Two cell lines, 402-91 and 1765-92, show a decrease in G1 and an increase in S-phase after treatment. DL-221 does not show a difference in cell cycle distribution (B).