Figure 5.

Experimental data documenting treatment dynamics of patient-derived bladder cancer mouse xenografts (A–C), and the dynamics of tumor growth without treatment (D). The tumors were treated with the chemotherapy regime gemcitabine and cisplatin (GC), treatment cycles are indicated in grey. Xenografts from three patient-derived cell lines are shown and designated as “sensitive”, “intermediate”, and resistant, based on qualitative observations. The “resistant” cell line data are re-plotted from Kurtova et al. (10), the data for the “intermediate” and “sensitive” xenografts were collected in the context of the same study but have not been previously published. Details of the experimental designs and the number of repeats are given in Kurtova et al. (10).