Fig. 1.

Functional MRI results for the observation of pain (v. no pain) and the manipulation of cognitive perspective taking (other v. self). A) Conjunction of the 2 groups for the pain > no pain contrast. B) Between-groups comparison for the pain > no pain contrast and β values extracted for each condition and group in the region showing a significant between-groups difference. C) Between-groups comparison for the PO1 > PS1 contrast and β values for each condition and group in brain regions showing a significant between-groups difference. D) Correlation between patients’ left temporoparietal junction/posterior superior temporal sulcus (TPJ/pSTS) activation during the PO1 condition and cognitive/disorganization symptoms. The threshold used for significance was p < 0.001, uncorrected, with k = 90. A less conservative threshold (k = 10) was used for regions with a priori hypotheses (anterior middle cingulate cortex [aMCC], bilateral anterior insula [AI] and TPJ). PANSS = Positive and Negative Syndrome Scale.