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. 2017 Jun 24;19(8):595–605. doi: 10.1016/j.neo.2017.04.006

Figure 1.

Figure 1

Deficiency of Stat6 reduces intestinal polyps in ApcMin/+ mice. (A) IL-4 and IL-4Rα mRNA expression in ApcMin/+ polyps (n = 5). UD, undetected. (B) Representative images (630× magnification) of immunohistochemical analysis of phospho-Stat6 in polyps from ApcMin/+ mice and nontumor small intestine tissue from WT. (C) Total polyp counts from each small intestine of ApcMin/+ (n = 14), ApcMin/+ Stat6+/− (n = 12), and ApcMin/+ Stat6−/− mice (n = 16). (D and E) Polyp counts in proximal, middle, and distal segments of the small intestine and number of polyps ≥3.0 mm, 2.0 mm, and 1.0 mm in the groups described above. Data in C to E are presented as box and whiskers plot, where median is shown by the center black line inside the box and min to max values are represented by the closed error bars. (F) Representative images of hematoxylin and eosin–stained sections of small intestine “Swiss rolls” at 100× magnification show intestinal polyps in mice from each group described above. Dashed areas indicate polyps. Scale bars = 1 mm. * P < .05, ** P < .005, *** P < .0005, ****P < .0001.