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. 2017 Jun 24;19(8):595–605. doi: 10.1016/j.neo.2017.04.006

Figure 5.

Figure 5

Reduction of MDSCs in ApcMin/+ mice deficient in Stat6. (A and B) Representative plots of M-MDSCs (CD11b+Ly6G−Ly6Chi), I-MDSCs (CD11b+Ly6GloLy6Cint), and PMN-MDSCs (CD11b+Ly6G+Ly6Clo) gated on CD45+CD11bhiCD11clo live splenocytes from ApcMin/+ (n = 6), ApcMin/+ Stat6+/− mice (n = 8), ApcMin/+ Stat6−/− mice (n = 8), and WT (n = 4). (C) Expression of Ly6C, Ly6G, and F4/80 on splenic I-MDSCs in the groups described above. (D and E) CD45+CD11b+CD11clo lamina propria cells from ApcMin/+ (n = 5), ApcMin/+ Stat6+/− mice (n = 8), ApcMin/+ Stat6−/− mice (n = 8), and WT (n = 3) were analyzed for M-MDSCs and PMN-MDSCs. Percentage of total CD45 cells is shown in plots. In WT mice, CD11b+Ly6G−Ly6C+ cells are monocytes and CD11b+Ly6G+Ly6Clo cells are neutrophils. * P < .05, ** P < .005, *** P < .0005, **** P < .0001.