Table 12.
Immune/inflammatory molecules among the 357 gene signatures of tolerance
| Categories | Diseases or functions annotation | Molecules | No. of molecules |
| Cell-to-cell signaling and interaction, cellular function and maintenance, hematological system development and function, inflammatory response | Phagocytosis of leukocyte cell lines | FGR, MRC1, TLR4 | 3 |
| Cell-to-cell signaling and interaction, hematological system development and function, immune cell trafficking, inflammatory response, tissue development | Binding of neutrophils | FGR, LSP1, TLR4 | 3 |
| Antimicrobial response, inflammatory response | Antibacterial response | CARD9, FGR, LYST, NLRC4, TLR4 | 5 |
| Cell-to-cell signaling and interaction, hematological system development and function, inflammatory response | Binding of professional phagocytic cells | FGR, LSP1, NOTCH2, TLR4 | 4 |
| Inflammatory response | Immune response of cells | CARD9, CLEC7A, ETS2, FGR, MRC1, SCARF1, MYO7A, TLR4 | 8 |
| Antimicrobial response, inflammatory response | Antimicrobial response | CARD9, CLEC7A, FGR, LYST, NLRC4, TLR4 | 6 |
| Inflammatory response | Innate immune response | CARD9, CLEC7A, TLR4, TRIM59 | 4 |
| Cellular function and maintenance, inflammatory response | Phagocytosis | CLEC7A, ETS2, FGR, MRC1, MYO7A, TLR4, TPCN2 | 7 |
| Cell-to-cell signaling and interaction, cellular growth and proliferation, hematological system development and function, inflammatory response | Stimulation of phagocytes | IL4R, TLR4 | 2 |
| Antimicrobial response, humoral immune response, inflammatory response | Antifungal response | CARD9, CLEC7A | 2 |
| Cell-to-cell signaling and interaction, cellular function and maintenance, inflammatory response | Phagocytosis of cells | CLEC7A, ETS2, FGR, MRC1,MYO7A, TLR4 | 6 |
These genes potentially predict those patients that can be successfully weaned off immunosuppression[133]. FGR: Tyrosine-protein kinase Fgr; MRC1: Mannose receptor, C type 1; TLR4: Toll-like receptor 4; FGR: Tyrosine-protein kinase Fgr; LSP1: Lymphocyte-specific protein 1; CARD9: Caspase recruitment domain family member 9; LYST: Lysosomal-trafficking regulator; NLRC4: NLR family CARD domain-containing protein 4; NOTCH2: Neurogenic locus notch homolog protein 2; CLEC7A: C-type lectin domain family 7 member A; ETS2: Protein C-ets-2; SCARF1: Scavenger receptor class F member 1; MYO7A: Unconventional myosin-VIIa; TRIM59: Tripartite motif-containing protein 59; TPCN2: Two pore calcium channel protein 2; IL4R: Interleukin 4 receptor.