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. 2017 Jun 24;7(3):161–178. doi: 10.5500/wjt.v7.i3.161

Table 12.

Immune/inflammatory molecules among the 357 gene signatures of tolerance

Categories Diseases or functions annotation Molecules No. of molecules
Cell-to-cell signaling and interaction, cellular function and maintenance, hematological system development and function, inflammatory response Phagocytosis of leukocyte cell lines FGR, MRC1, TLR4 3
Cell-to-cell signaling and interaction, hematological system development and function, immune cell trafficking, inflammatory response, tissue development Binding of neutrophils FGR, LSP1, TLR4 3
Antimicrobial response, inflammatory response Antibacterial response CARD9, FGR, LYST, NLRC4, TLR4 5
Cell-to-cell signaling and interaction, hematological system development and function, inflammatory response Binding of professional phagocytic cells FGR, LSP1, NOTCH2, TLR4 4
Inflammatory response Immune response of cells CARD9, CLEC7A, ETS2, FGR, MRC1, SCARF1, MYO7A, TLR4 8
Antimicrobial response, inflammatory response Antimicrobial response CARD9, CLEC7A, FGR, LYST, NLRC4, TLR4 6
Inflammatory response Innate immune response CARD9, CLEC7A, TLR4, TRIM59 4
Cellular function and maintenance, inflammatory response Phagocytosis CLEC7A, ETS2, FGR, MRC1, MYO7A, TLR4, TPCN2 7
Cell-to-cell signaling and interaction, cellular growth and proliferation, hematological system development and function, inflammatory response Stimulation of phagocytes IL4R, TLR4 2
Antimicrobial response, humoral immune response, inflammatory response Antifungal response CARD9, CLEC7A 2
Cell-to-cell signaling and interaction, cellular function and maintenance, inflammatory response Phagocytosis of cells CLEC7A, ETS2, FGR, MRC1,MYO7A, TLR4 6

These genes potentially predict those patients that can be successfully weaned off immunosuppression[133]. FGR: Tyrosine-protein kinase Fgr; MRC1: Mannose receptor, C type 1; TLR4: Toll-like receptor 4; FGR: Tyrosine-protein kinase Fgr; LSP1: Lymphocyte-specific protein 1; CARD9: Caspase recruitment domain family member 9; LYST: Lysosomal-trafficking regulator; NLRC4: NLR family CARD domain-containing protein 4; NOTCH2: Neurogenic locus notch homolog protein 2; CLEC7A: C-type lectin domain family 7 member A; ETS2: Protein C-ets-2; SCARF1: Scavenger receptor class F member 1; MYO7A: Unconventional myosin-VIIa; TRIM59: Tripartite motif-containing protein 59; TPCN2: Two pore calcium channel protein 2; IL4R: Interleukin 4 receptor.