Table 13.

Immunosuppression-independent gene signatures predicting tolerance[134]

Symbol	Gene name	Molecular function	Biological processes
ATXN3 ↓	Ataxin 3	Ubiquitin-specific protease activity	Protein metabolism
BCLA1 ↓	BCL2-related protein A1	Receptor signaling complex scaffold activity	Apoptosis
EEF1A1 ↓	Eukaryotic translation elongation factor 1 alpha 1	Transcription regulator activity	Regulation of cell cycle
GEMIN7 ↑	Gem associated protein 9	Ribonucleoprotein	Regulation of nucleobase, nucleosides, nucleotide and nucleic acid metabolism
IGLC1 ↑	Immunoglobulin lambda constant 1	Antigen binding	Immune response
MS4A4A ↑	Membrane-spanning 4-domains, subfamily A, member 4A	- - -	- - -
NFκBIA ↑	Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Transcription regulator activity	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
RAB40C ↑	RAB40C, member of RAS oncogene family	GTPase activity	Cell communication, signal transduction
TNFAIP3 ↓	Tumor necrosis factor, alpha-induced protein 3	Transcription regulator activity	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism

↓Immunosuppression-free gene expression downregulated in tolerant patients; ↑Immunosuppression-free gene expression upregulated in tolerant patients; BCL2: B-cell lymphoma 2.