Table 2.

Distribution of differentially methylated CpGs among HPO methylomes.

	Detected CpGs	DMCs between Hypothalamus and Pituitary		DMCs between Hypothalamus and Ovary		DMCs between Pituitary and Ovary
		Number	Enrichment	Number	Enrichment	Number	Enrichment
Total	1,403,700	14,744	—	33,809	—	29,759	—
CGI	556,039	3,509	0.48 (P < 2.22 × 10−16)	7,313	0.42 (P < 2.22 × 10−16)	7,612	0.52 (P < 2.22 × 10−16)
CGI shores	294,560	3,452	1.15 (P = 1.20 × 10−12)	8,044	1.18 (P < 2.22 × 10−16)	7,391	1.24 (P < 2.22 × 10−16)
CGI shelves	98,913	1,262	1.23 (P = 4.48 ×  10−12)	3,383	1.47 (P < 2.22 × 10−16)	2,493	1.21 (P < 2.22 × 10−16)
Upstream	175,419	1,189	0.61 (P < 2.22 × 10−16)	2,308	0.51 (P < 2.22 × 10−16)	2,529	0.65 (P < 2.22 × 10−16)
Exon	228,324	1,340	0.51 (P < 2.22 × 10−16)	2,848	0.47 (P < 2.22 × 10−16)	2,661	0.51 (P < 2.22 × 10−16)
Intron	369,473	4,359	1.17 (P < 2.22 × 10−16)	9,303	1.06 (P = 9.39 × 10−7)	7,838	1.00 (P = 0.95)
Downstream	89,868	919	0.97 (P = 0.42)	2,114	0.98 (P = 0.27)	1,706	0.89 (P = 2.22 × 10−6)
Intergenic	540,616	6,937	1.42 (P < 2.2 × 10−16)	17,236	1.66 (P < 2.22 × 10−16)	15,025	1.63 (P < 2.22 × 10−16)

The enrichment of DMCs for certain genomic regions was using with a two-tail Fisher’s exact test.