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. 2017 Jun 27;7:4299. doi: 10.1038/s41598-017-04082-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cilostazol reduced the extent of gliosis. (a) Representative images of Iba1 staining in the corpus callosum. (b) There was a trend towards an increase in Iba1 stained micoglia that was reduced with cilostazol after hypoperfusion. There was a robust association between microgliosis and the number of revisiting errors (Pearson r = 0.712, p < 0.0001). (c) Representative images of immunofluorescence for Collagen IV, AQP4 and GFAP in the corpus callosum. (d) There was an increase in the area of GFAP positive astroglia in the hypoperfused-control mice. There was a significant reduction with cilostazol treatment as compared to control hypoperfused. Astrocyte-endfoot displacement tended to be observed in the hypoperfused-control mice and less in the cilostazol treated mice. Data represents mean ± SEM. *p < 0.05, Hypoperfused-control vs Hypoperfused-cilostazol.