Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 27;7:4305. doi: 10.1038/s41598-017-04677-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Brain activity changes associated with oxaliplatin-induced cold hypersensitivity. Three days after oxaliplatin infusion, increased activation in the secondary somatosensory cortex (SII) and the insular cortex (Ins) in both hemispheres, compared with activation before oxaliplatin infusion (“Intact”) (c.f. Table 1), were associated with low-temperature stimulation (i.e., activity in response to 10 °C stimulation minus activity in response to 37 °C (control) stimulation). (a) Results of subject-level analysis. Increased activation in SII/Ins (arrows) is observed in all four oxaliplatin-treated macaques. (b) Results of group-level analysis. A series of coronal slices, spaced 2 mm apart, are arranged from rostral (upper left, y = 24) to caudal (lower right, y = −10). Cb, cerebellum. (c) Peak voxels were located in the anterior SII/Ins of both hemispheres (arrows). The arrows indicate peak voxels in each hemisphere.