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. 2017 Jun 27;7:4305. doi: 10.1038/s41598-017-04677-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of duloxetine on brain activity in oxaliplatin-treated macaques. (a) Systemic duloxetine ameliorated oxaliplatin-induced cold hypersensitivity; withdrawal latencies to 10 °C in either cycle were significantly increased (***P < 0.001, Paired t-test). Values are expressed as mean ± SD. (b) After duloxetine treatment, voxels in the secondary somatosensory cortex (SII) and the insular cortex (Ins) were no different compared to that of intact (pre-oxaliplatin infusion) macaques, (P < 0.01, uncorrected). (c) Activation in the SII and Ins was significantly decreased after duloxetine treatment, compared with brain activity before duloxetine treatment (P < 0.01, uncorrected; Table 4). In (b) and (c), a series of coronal slices, spaced by 4 mm, are arranged from rostral (upper-left, y = 24) to caudal (lower-right, y = −16). Cb, cerebellum; MI, primary motor cortex.