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. 2017 Jun 27;7:4292. doi: 10.1038/s41598-017-04612-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ACF inhibits HSR-GBM1-Luc xenograft growth in vivo. (A) HSR-GBM1 xenografts were grown to approximately 220 mm³. Treatment was administered by intraperitoneal injections of vehicle (DMSO in saline) or ACF (8 mg/kg) for 15 injections (indicated by arrows in (A)). Tumor volume (mean +/− SEM; n = 5) is shown. (B) To determine if ACF is reaching its target in vivo, two mice (one female and one male) were euthanized on day 41 (Third daily injection and 2 hours after the last dose) and their tumors were harvested and analyzed by flow cytometry, with HSR-GBM1-Luc serving as a reference. (C,D) Microvessel density analysis for xenografts shown in (A) using IHC staining for CD31; **P < 0.01 ACF vs. vehicle (two-way ANOVA with Sidak’s multiple comparisons test).