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. 2017 Jun 27;7:4261. doi: 10.1038/s41598-017-00686-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High D-glucose induced PLK2 expression. (A,B) Representative blots of PLK2 upregulation with different D-glucose concentrations. (C,D) Lentiviral encoding shRLK2 significantly reduces PLK2 expression in the presence of HDG in mouse podocytes. (E) Cell viability in response to HDG was significantly improved in shPLK2 group in mouse podocytes using CCK-8 assay. **P < 0.01.