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. 2017 Jun 27;7:4272. doi: 10.1038/s41598-017-04496-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Skin lesions based on radiation dose in a radiation-induced dermatitis model. (A) Photographs of radiation-induced lesions 3 weeks post-exposure: (a) 25 Gy, (b) 35 Gy and (c) 45 Gy, (d) 55 Gy, (e) 65 Gy, (f) 75 Gy. (1B) Macroscopic time-lapse observation of skin lesions following 55 Gy exposure. (1C) (a) Severity of lesions. (b) Average lesion score 4 weeks after irradiation. 14 groups (n = 10 rats in each group). The first group consisted of un-irradiated rats. Five groups were irradiated at 25, 35, 45, 55, 65, and 75 Gray (Gy). Each group of animals comprised 10 Sprague Dawley rats. Comparison by ANOVA followed by the Mann-Whitney or Dunnett’s test for group pair-wise comparisons. Data represent mean ± SEM, ns: not significant, *p < 0.05, **p < 0.01, ***p < 0.001.